Human thyroid-ovarian relationships: I. Influence of serum from various phases of ovarian cycle on goitrogenesis

Abstract

1.1. Pooled serum from healthy adult males has no significant effect upon goitrogenesis in the rat.2.2. Pooled serum from the luteal phase of the menstrual cycle enhances goitrogenesis significantly; in contrast, pooled serum from the follicular phase shows some tendency to inhibit goitrogenesis, although this is not statistically significant.3.3. Menstrual and late luteal serum pools show effects upon goitrogenesis which support the concept of a thyroid cycle consonant with the ovarian cycle. The thyroid cycle appears to reach its height of activity during the premenstrual phase of the ovarian cycle and returns to its lowest level during the follicular phase.4.4. These constructs are in keeping with clinical observations of the normal male and with sequential observation of the normal female during the various phases of the ovarian cycle.