Abstract
There is evidence that there may be bidirectional communication between immune and gonadotropin producing cells. In the present study we describe the secretion and function of an LH like peptide secreted from the human thymus. Serial dilutions of thymic extracts obtained from surgically removed thymic tissues displaced I 125 LH from LH antiserum parallel to that produced by pituitary LH. Thymic LH was detected as early as 10 days of age and maximal concentrations were noted at 5 months. Utilizing a sensitive and specific hormonal enzyme linked immunoplaque assay developed in our laboratory, we were able to detect LH secretion from unstimulated human thymocytes. Neutralizing endogenously released LH in PHA stimulated thymocytes with LH antiserum significantly inhibited thymidine incorporation. We conclude that an LH-like peptide is secreted by human thymocytes which acts as an autocrine co-mitogen in lymphoproliferation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
