Abstract
Idiopathic oligospermia is generally associated with a normal sexual function, behavior and blood hormonal levels. As it has been said that high intrateslicular levels of testosterone are necessary for normal spermatogenesis we conducted a pilot study aimed to investigate the possible mechanisms involved in testosterone concentration by the tubular compartment in humans. Superfusion studies were conducted on biopsies from normal men (as judged by hormonal and semen analysis) and in three infertile patients. Uptake and metabolism of tracers were similar in all groups. However, infertile men appear to synthetize less and secrete more androstenedione. These changes result in less A available at the tubular level and as A to T conversion is similar in all cases, less T is formed from the A pool in infertile men.
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