Abstract
Objective To investigate the pathogenesis o f lung cancer in population of Xuanwei with higher incidence and characteristic histologic type. Methods 29 specimens of lung cancer from Xuanwei(Group X) and 11 specimens of lung cance r from other regions(Group NX) were detected for Ki-67 growth fraction and huma n telomerase RNA(hTR) expression by means of immunohistochemistry and in situ hy bridization respectively. Results Ki-67 labeling index of Group X(34.4%±17.8%) was stati stically significantly higher than that of Group NX(21.9%±11.2%,P=0.045). No significant difference was observed with regard to the positive rate of hTR expression between Group X and Group NX(55.2% vs. 72.7%,P=0.31).However ,it was found that there was 45.5%(5/11) of patients with positive detection of hTR in the proliferating Ⅱ type alveolar epithlia adjacent to the cancer in Gro up NX. Conclusion The characteristic cause of lung cancer in Xuanwei may lead to its difference in cell kinetics from lung cancer of general people.hTR may be a valuable indicato r of lung malignancy for early diagnosis of lung cancer.
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