Abstract
How T cells are transformed by HTLV-1 is still unclear, but it is well accepted that the viral oncoprotein Tax is associated with genomic instability of infected cells. Tax has recently been shown to directly induce, in T cells, the expression of AID (Ishikawa C et al., Carcinogenesis, 2011), a cytidine deaminase whose physiologic expression is usually restricted to B cells, in which it initiates class-switch recombination and somatic hypermutations to reshape the primary antibody repertoire after antigen encounter. It is also well established that AID-mediated mutations outside of immunoglobulin gene locus are involved in the oncogenic transformation of B lymphocytes...
Highlights
How T cells are transformed by Human T-cell leukemia virus type 1 (HTLV-1) is still unclear, but it is well accepted that the viral oncoprotein Tax is associated with genomic instability of infected cells
Besides its role in B cell lymphomagenesis, Activation-Induced cytidine Deaminase (AID) was recently proposed to play a key role in different human cancers linked to chronic inflammation, or in cancers associated with infectious agents
We first confirmed that both Tax+ and HTLV-1-infected T-cell lines, but not uninfected T cells expressed aid mRNA as well as AID protein
Summary
How T cells are transformed by HTLV-1 is still unclear, but it is well accepted that the viral oncoprotein Tax is associated with genomic instability of infected cells. Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID) From 16th International Conference on Human Retroviruses: HTLV and Related Viruses Montreal, Canada.
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