Abstract
Somatic cell hybridization first described by Barski et al. (1) initiated an era in cell biology wherein differential genetic and functional properties could be expressed and regulated in the same cell. This approach was utilized by Milstein and Kohler (2) to combine the properties of specific antibody secretion and continuous growth in vitro when they successfully fused normal mouse B lymphocytes with enzyme-deficient mouse myeloma cells.KeywordsPeripheral Blood LymphocyteTetanus ToxoidHelper ActivityNormal Peripheral BloodSpecific Antibody ProductionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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