Abstract
Employing viscometry, human spectrin heterodimers and heterotetramers were analyzed in aqueous solution containing different amounts of salt. 1. (1) In aqueous 0.1 M NaCl, pH 7.5, at 4°C, the intrinsic viscosity of isolated human spectrin heterodimers and heterotetramers was found to be 40 ± 6 and 79 ± 7 ml/g , respectively. 2. (2) The intrinsic viscosity of isolated human spectrin heterodimers and heterotetramers increased to 78 ± 8 and 180 ± 10 ml/g , respectively, as the ionic strength of the solution was reduced to about 2 mM. 3. (3) This viscometric study indicates that isolated human spectrin heterodimers and heterotetramers are flexible molecules with a contour length of at least 110 and 200 nm, respectively.
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