Abstract
Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmolFe ml−1, which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.
Highlights
Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage
The common clinical imaging techniques used for the brain are computed tomography (CT) and magnetic resonance imaging (MRI)
CT has a high spatial resolution, but it exposes the patient to radiation, and in turn should not be used for recurring monitoring applications after stroke treatment
Summary
Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. The device is based on the magnetic particle imaging technology and is designed for human scale It is highly sensitive and allows the detection of an iron concentration of 263 pmolFe ml−1, which is one of the lowest iron concentrations imaged by MPI so far. MRI mainly suffers from a limited accessibility for intensive care unit (ICU) patients and relatively long examination times As both techniques require dedicated rooms, no modality is currently available for continuous monitoring of the brain perfusion within the ICU. The major barrier for the transition from a preclinical setting to clinical use and the application of MPI on a human-scale has been the lack of an imaging device with sufficient bore size. Simulation studies on the design of a functional MPI brain imager proved promising capabilities for human scale systems[23]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
