Abstract
A commercial, low pH-derived, intravenously applicable human IgG immunoglobulin preparation (Sandoglobulin®) revealed O-agglutinin activity against 16 of the 21 O-antigens of Serratia marcescens, although at low titers; this IgG preparation lacked H-immobilizing antibodies against this microorganism. The bactericidal activity of 65 vol% of normal, fresh human serum was neither enhanced nor significantly antagonized following addition of 25 vol% of undiluted or 1:4 diluted Sandoglobulin®, as determined with test strains of S. marcescens that represented various human serum susceptibility categories. This indifferent effect was obtained despite documented O-agglutinin activity directed against several of the assay strains. It was concluded tentatively, that human, ‘natural’ anti S. marcescens IgG antibodies failed to augment human serum bactericidal activity in vitro against this opportunistic-pathogenic microorganism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene / A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
