Abstract
BackgroundWe describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.MethodsFrom September 1, 2003–August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.ResultsHRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1–4 year: 29%, ≥65 years: 9%; controls: <1 year: 24%, 1–4 year: 14%, ≥65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1–4 years (457), and ≥65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1–4 year (51%) and 5–19 year age groups (54%). Compared to controls, hospitalized adults (≥19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.ConclusionsHRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.
Highlights
Human rhinoviruses (HRVs) are members of the family Picornaviridae, genus Enterovirus, and comprise 3 species, human rhinovirus (HRV)-A, HRV-B and the recently recognized HRV-C [1,2,3]
Some studies suggest that infection with HRV-C may result in more severe illness compared to illness with other species [1,2,16,17]
We looked for clinical evidence that co-detection of HRV with respiratory syncytial virus (RSV) might be similar to clinical illness associated with RSV and be different than illness associated with HRV only detections
Summary
Human rhinoviruses (HRVs) are members of the family Picornaviridae, genus Enterovirus, and comprise 3 species, HRV-A, HRV-B and the recently recognized HRV-C [1,2,3]. Several studies have suggested that HRVs may be associated with more severe illness, including hospitalized lower respiratory disease and asthma exacerbations [5,6] [7,8,9,10,11,12,13,14,15]. Some studies suggest that infection with HRV-C may result in more severe illness compared to illness with other species [1,2,16,17]. We took advantage of a study in rural Thailand that concurrently enrolled hospitalized patients with acute lower respiratory illness, a sample of outpatients with influenza-like illness, and control outpatients without fever or respiratory symptoms from the same hospitals to better define the etiologic role of HRV infection and associated disease burden in this community. We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
