Abstract
Background: The conditions caused by BK polyomavirus (BKV) reactivation are gaining important clinical significance in kidney transplant centers worldwide. Methods: For the first time in Bulgaria, we tried to perform investigations on BKV reactivation on a selected group of kidney transplant patients. By the use of surrogate diagnostic markers— urine cytology and PCR on urine/plasma—we tried to evaluate their BKV reactivation and also in related recipient pairs. Sequence analysis was also applied in order to relate the viral genotype to the unfavorable prognosis, where observed. Results: The high incidence of viruria among allograft recipients (n=42/50, 84%) was linked occasionally to BKV disease, only in n=2/50 (4%) patients, presumptive BK-associated nephropathy (BKAN). BKAN genotypes analyzed by sequencing belonged to one genotype, which is frequently observed. BKV reactivation prior to transplantation in related transplant pairs was 25% (n=2/8) in the recipients who had viruria and viremia at the same time.
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