Abstract
Four ether analogs of lysophosphatidic acids (LPA) have been prepared. They include 1-hexadecyl-sn-glyceryl-3-phosphate (1-Hx-GPA), 1-hexadecyl-2-acetyl-sn-glyceryl-3-phosphate (1-Hx-2-Ac-GPA) and their respective enantiomers. The four compounds promoted human platelet aggregation. 1-Hx-GPA was found 10 times less potent than platelet activating factor (PAF-acether), but 30 times more powerful than 1-palmitoyl-sn-glyceryl-3-phosphate (1-P-GPA). The four compounds did not display any strong stereospecificity and acetylation of the 2-hydroxyl-group was not essential for full activity. Moreover, they all displayed specific platelet desensitization to 1-Hx-GPA, but not to PAF-acether. It is concluded that ether analogs of LPA represent a new group of powerful phospholipid mediators acting by a mechanism in some way different from that of PAF-acether.
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