Abstract
Data obtained from immunologic and biologic assays of trophoblast, pituitaries, urine, and sera of pregnant women demonstrate a similar pattern of production and excretion of human placental lactogen (HPL) as that already known for human chorionic gonadotropin (HCG). The placental secretion of HPL may well be essential for the development of the corpus luteum of pregnancy. HPL is also shown to markedly potentiate the anabolic effects of human pituitary growth hormone (HGH) in growth assays performed in hypophysectomized rats. It is, therefore, proposed that HPL is a second hormone, unique to fetal trophoblast.
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