Abstract
BackgroundThe human placenta (HP) is a complex organ used to alleviate tiredness and promote wound healing. Previous research showed the hair growth-promoting effect of HP. However, no reports have addressed the effects of HP on hair regrowth in chemotherapy-induced alopecia. In this study, we investigated the effects of HP on the apoptosis and proliferation of hair follicles in chemotherapy-induced alopecia.MethodsMale C57BL/6 mice in telogen were depilated to enter anagen. After 9 days, dystrophic catagen was induced by the intraperitoneal injection of 150 mg/kg cyclophosphamide. During 9 to 16 days, 0.1 and 1 mg/mL HP were topically applied to depilated dorsal skin.ResultsDystrophic hair follicles by cyclophosphamide were recovered by HP treatment. New hair shafts containing hair fibers appeared to be straight after HP treatment. Immunohistological staining revealed a significant increase of Ki67-positive cells in hair follicles treated with 1 mg/mL HP. Topical HP treatment increased the ratio of Bcl-2/Bax, while it attenuated the expression of pro-apoptotic Bax, p53, and cytochrome c with caspase-9 and -3. In addition, the expression of KGF and the phosphorylation of AKT were upregulated by HP treatment.ConclusionThese results suggest that HP treatment induced hair growth by inhibiting apoptosis and promoting the proliferation of hair follicles. HP may be useful for treating chemotherapy-induced alopecia.
Highlights
The human placenta (HP) is a complex organ used to alleviate tiredness and promote wound healing
HP recovers dystrophic hair follicles Broken hair shafts did not emerge from hair follicles on the skin surface in the CYP group
Treatment with HP led to the recovery of tapering hair shaft length and broken hair follicles (Fig. 1)
Summary
The human placenta (HP) is a complex organ used to alleviate tiredness and promote wound healing. No reports have addressed the effects of HP on hair regrowth in chemotherapy-induced alopecia. We investigated the effects of HP on the apoptosis and proliferation of hair follicles in chemotherapy-induced alopecia. Chemotherapy-induced alopecia (CIA) is a psychologically devastating side effect for patients common to certain therapeutic regimens in oncology [1]. Novel chemotherapies are continually being developed, but hair loss consistently ranks among their associated features that are troublesome and distressing to Multiple therapeutic agents for treating CIA have been proposed, such as scalp hypothermia, minoxidil, and. The efficacy of minoxidil is limited and transient because hair loss resumes after its use is discontinued [5]. There are still considerable problems associated with calcitriol, including limited supply, high manufacturing costs, excessive inflammation, and various disease risks [6]. There is a need to develop more effective and satisfactory management strategies for CIA in the field of clinical oncology
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