Abstract
Human peripheral lymphocyte (PL) cultures are a widely used test system for the analysis of chromosomal aberrations and sister chromatid exchanges (SCE), induced either in vivo or in vitro. The analysis of chromosomal aberrations and SCE’s in PL of exposed individuals still represents the only feasible method for the determination of mutagenic damage induced in man in vivo. The methodology and various aspects of “the human leukocyte test system” have been reviewed extensively (Buckton and Evans 1982; Crossen 1982; Gebhart 1982; Obe and Beek 1982a; Obe and Madle 1981; Natarajan and Obe 1980, 1982). In the following section we shall focus only on some special aspects and recent advantages concerning the “human leukocyte test system”, namely: 2. Stimulation of peripheral lymphocytes in vitro. 3. Inter-individual variabilities in induced chromosomal alterations and in repair capacities. 4. Intra-individual variabilities — the problem of subpopulations. 5. Fragile sites in human chromosomes.
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