Abstract
Parvovirus B19 infects predominantly erythroid cells, leading to transient inhibition of erythropoiesis. Immunocompromised patients may be unable to produce neutralizing antibodies and may develop severe chronic anemia. Epidemiological studies done on Niterói population showed that B19 infection occurs periodically in late spring and summer. We report a study from 55 HIV infected patients attending an infectious diseases outpatient clinic in this city during a 5-month period in which B19 circulation was well documented. All patients were under anti-retroviral therapy. No anti-B19 IgM was found, but a high prevalence of IgG anti-B19 (91%) was observed. In six patients, B19 DNA was found by dot-blot hybridization techniques, but this was not confirmed by PCR. None of these 6 patients manifested anemia and only one had CD4 cell count below 200 x 10(7)/L. We conclude that persistent infection causing anemia is an infrequent finding in our HIV positive patients under drug therapy.
Highlights
Parvovirus B19 infects predominantly erythroid cells, leading to transient inhibition of erythropoiesis
Anemia is a common finding in the HIV infected patient[1 12]
Several causes of anemia have been described in HIV positive patients[13], such as the drugs used in the course of treatment, lymphomas, the direct effect of HIV on bone marrow cells and coinfection with mycobacteria or human parvovirus B19
Summary
Parvovirus B19 infects predominantly erythroid cells, leading to transient inhibition of erythropoiesis. Conclui-se que infecção persistente causando anemia é um achado infreqüente em nossos pacientes HIV positivos sob terapia medicamentosa. Human Parvovirus B19 is a member of the Parvoviridae family and infects predominantly erythroid stem cells. This results in transient inhibition of erythropoiesis[5]. B19 infection causes severe chronic anemia due to inability to produce neutralizing antibodies, and consequent persistence of virus replication[14]. In this study we examined the prevalence of antiB19 IgG antibodies, and sought evidence of persistent B19 infection, in HIV infected individuals attending the outpatient clinic of the Infectious Diseases Department of Hospital Universitário Antônio Pedro, a public tertiary care university hospital in Niterói
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