Abstract
To the Editor: Human parvovirus 4 (PARV4) is a recently identified virus, distantly related to already known members of the family Parvoviridae that affect humans and animals. Initially, PARV4 was characterized in the blood of a North American patient who had acute viral syndrome; a sequence-independent amplification approach was used (1). Molecular analysis of the viral prototype genome (5,268 nt) identified 2 large, nonoverlapping open reading frames (ORFs) and showed limited homology with human parvovirus B19 (<30% aa similarity). Subsequent phylogenetic analyses have shown that at least 2 genotypes are identifiable, differing by ≈8% at the nucleotide level (2).
Highlights
To the Editor: Human parvovirus 4 (PARV4) is a recently identified virus, distantly related to already known members of the family Parvoviridae that affect humans and animals
The first prevalence studies, performed mainly in North America and the United Kingdom, reported finding the virus in plasma samples from febrile patients who had symptoms resembling those of acute HIV infection (6%), from cadavers of hepatitis C RNA–positive intravenous drug users (30%), and in plasma donations from healthy blood donors (5% pooled, 2% individual) [3,4,5]
PARV4 was identified in clotting factor VIII concentrate and in plasma pools negative for parvovirus B19 DNA [5,6]
Summary
To the Editor: Human parvovirus 4 (PARV4) is a recently identified virus, distantly related to already known members of the family Parvoviridae that affect humans and animals. PARV4 was identified in clotting factor VIII concentrate and in plasma pools negative for parvovirus B19 DNA [5,6]. Typical amounts of PARV4 DNA identified in the various samples tested ranged from 106 copies/mL.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
