Abstract
Information about human parechovirus (HPeV) infection in animals is scant. Using 5' untranslated region reverse transcription-PCR, we detected HPeV in feces of monkeys with diarrhea and sequenced the complete genome of 1 isolate (SH6). Monkeys may serve as reservoirs for zoonotic HPeV transmissions and as models for studies of HPeV pathogenesis.
Highlights
Information about human parechovirus (HPeV) infection in animals is scant
HPeV-1 and HPeV-2, formerly known as echovirus 22 and echovirus 23, were originally considered to belong to the genus Enterovirus (1,2) but after genome sequencing were reclassified as members of a new genus in the family Picornaviridae (3)
6 other genotypes of parechovirus were isolated from young children with gastrointestinal, respiratory, and severe neurologic signs (4–11)
Summary
Information about human parechovirus (HPeV) infection in animals is scant. Using 5′ untranslated region reverse transcription–PCR, we detected HPeV in feces of monkeys with diarrhea and sequenced the complete genome of 1 isolate (SH6). Members of the human parechovirus (HPeV) species are small, nonenveloped RNA viruses that are members of the family Picornaviridae, genus Parechovirus. HPeV can be classified into at least 8 genotypes on the basis of sequence similarity of their capsid protein (HPeV-1–HPeV-8). HPeV-1 and HPeV-2, formerly known as echovirus 22 and echovirus 23, were originally considered to belong to the genus Enterovirus (1,2) but after genome sequencing were reclassified as members of a new genus in the family Picornaviridae (3). Other HPeV genotypes continue to be characterized
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