Human Papillomavirus Prevalence in Urine Samples of Asymptomatic Male Sexual Partners of Women with Sexually Transmitted Diseases.

Hyunwoo Jin,Kyung Eun Lee,Dong Hyeok Kim

doi:10.3390/ijerph182111706

Abstract

Human papillomavirus (HPV) infection in males is associated with various cancers, including cervical cancer in women and penile and bladder cancers in men. However, there is limited research on the prevalence and prevention of male HPV infection. Moreover, a rapid test that can prevent the increase in HPV infection is needed. In this study, the prevalence of sexually transmitted pathogen (STP) and HPV infection was analyzed using real-time polymerase chain reaction assay in random urine samples collected from asymptomatic male sexual partners of women with sexually transmitted diseases. Among 130 men, 65 (50.0%) had STP and 12 (9.23%) had HPV infection. There was no association between STP and HPV infection. Among 12 cases of HPV infection, three were HPV-16 single infections, six were multiple infections, including HPV-16, and three of other high-risk HPV infections. Our results suggest the need for STP testing, including HPV testing, in sexual partners of high-risk women with sexually transmitted diseases, even in men without clinical symptoms (asymptomatic). Further research should be conducted by diversifying urine samples. We report the most convenient method for HPV detection, and it is expected to be widely applied to prevent sexually transmitted diseases in men and women.

Highlights

Among the sexual partners of sexually transmitted disease (STD)-positive women, a total of 130 men visited the hospital for complete treatment, and none of them had clinical symptoms
Transmitted pathogen (STP) detection showed a positive result in 65 patients (50.0%) out of 130 random urine samples of men
Ureaplasma parvum infection occurred in 9.4% of patients (8/85), Chlamydia trachomatis infection occurred in 5.9% (5/85), Mycoplasma hominis infection occurred in 5.9% (5/85), and Mycoplasma genitalium infection occurred in 1.2% (1/85) (Table 1)

Summary

Introduction

Human papillomavirus (HPV) is a sexually transmitted disease (STD) that is a major cause of cervical cancer in women. It has been reported that HPV is related to penile, anogenital, bladder, lung, and oropharyngeal cancers in men [1,2]. Studies on the prevalence of HPV infection in men are insufficient compared to that in women, previous studies have reported that the prevalence of HPV infection is high in men who are sexual partners of women with an STD and women with human immunodeficiency virus infection [3]. The prevalence of HPV infection among men in Asia was reported to be lower than that among men in Africa, Europe, and the United States [4,5]

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