Abstract
To investigate the relationship between human papillomavirus (HPV) infection and prostatitis-related symptoms. All young heterosexual patients with prostatitis-related symptoms attending the same Center from January 2005 to December 2010 were eligible for this case-control study. Sexually active asymptomatic men were considered as the control group. All subjects underwent clinical examination, Meares-Stamey test and DNA-HPV test. Patients with prostatitis-related symptoms and asymptomatic men were compared in terms of HPV prevalence. Moreover, multivariable Cox proportional hazards regression analysis was performed to determine the association between HPV infection and prostatitis-related symptoms. Overall, 814 out of 2,938 patients (27.7%) and 292 out of 1,081 controls (27.0%) proved positive to HPV. The HPV genotype distribution was as follows: HR-HPV 478 (43.3%), PHR-HPV 77 (6.9%), LR-HPV 187 (16.9%) and PNG-HPV 364 (32.9%). The most common HPV genotypes were: 6, 11, 16, 26, 51, 53 and 81. No difference was found between the two groups in terms of HPV infection (OR 1.03; 95% CI 0.88-1.22; p = 0.66). We noted a statistically significant increase in HPV infection over the period 2005 to 2010 (p < 0.001) in both groups. Moreover, we found a statistically significant increase in HPV 16 frequency from 2005 to 2010 (p = 0.002). This study highlights that prostatitis-like symptoms are unrelated to HPV infection. Secondary, we highlight the high prevalence of asymptomatic HPV infection among young heterosexual men.
Highlights
Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in both genders [1]
We investigated HPV infection prevalence in young heterosexual males with prostatitis-related symptoms in order to find a possible relationship between HPV infection and prostatitis-related symptoms
814 out of the 2,938 patients (27.7%) and 292 out of the 1,081 controls (27.0%) proved positive to HPV (Odds ratio [OR] 1.03; 95% confidence intervals (CI) 0.88-1.22; p = 0.66)
Summary
Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in both genders [1]. The prevalence of HPV in males ranges from 7% to 45% [4], but the majority ibju | HPV symptoms in young sexually active men of studies have been conducted on homosexuals, HIV patients or infertile men [5,6]. Klinglmair et al found a high prevalence of HPV infection in a cohort of 250 young males, including children (0-10 years), indicating non-sexual transmission pathways [7]. We investigated HPV infection prevalence in young heterosexual males with prostatitis-related symptoms in order to find a possible relationship between HPV infection and prostatitis-related symptoms. The present case-control study aimed to determine whether HPV infection could be considered a risk factor of prostatitis-related symptoms in young heterosexual males
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