Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis.

Jong-Myon Bae,Eun Hee Kim

doi:10.4178/epih/e2015052

Abstract

OBJECTIVES:The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW.METHODS:Based on a prior SR and some expert reviews, we identified refereed, cited, or related articles using the PubMed and Scopus databases. All case-control studies that reported the odds ratio of HPV infection in LCNSW were selected. An estimate of the summary odds ratio (SOR) with 95% confidence intervals (CI) was calculated.RESULTS:A total of four case-control studies were included. The fixed-effect model was applied because of homogeneity (I-squared=0.0%). The SORs in women and in never-smokers were 5.32 (95% CI, 1.75 to 16.17) and 4.78 (2.25 to 10.15) respectively.CONCLUSIONS:These results showed a significant effect of HPV infection in LCNSW. It is evident that developing a preventive plan against LCNSW may be necessary.

Highlights

Lung cancer ranks the first in cancer mortality in Korea and is the primary cancer with the heaviest disease burden [1]
These results showed a significant effect of human papillomavirus (HPV) infection in lung cancer in never-smokers and women (LCNSW)
According to the 2002-2012 statistics on lung cancer provided by Statistics Korea, the incidence rate in women increased and the rate of adenocarcinoma increased during this time period [2]

Summary

Introduction

Lung cancer ranks the first in cancer mortality in Korea and is the primary cancer with the heaviest disease burden [1]. According to the 2002-2012 statistics on lung cancer provided by Statistics Korea, the incidence rate in women increased and the rate of adenocarcinoma increased during this time period [2]. These facts were corroborated by a study on lung cancer patients treated at a local cancer center [3], and the study authors reported that the majority of women with lung. A modifiable risk factor, human papillomavirus (HPV) infection, may be involved [6,7,9] It is a risk factor for many cancers, such as cervical cancer [13], prostate cancer [14], and breast cancer [15], and currently, preventive vaccines are commercially available [16]

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