Human papillomavirus immunohistochemistry in high grade squamous cell lesions of esophagus

Abstract

Background: Over the past decade, the cause–effect relationship between human papillomavirus (HPV) and squamous cell carcinoma (SCC) of the esophagus has been worked over. A few reports in the literature have demonstrated HPV protein within premalignant and malignant cells of SCC of the esophagus. Aims and Objectives: The aim was to study the high-grade squamous cell lesions and its relation with high-risk HPV infection to be evident on immunohistochemistry for high-risk HPV on biopsies of esophageal lesions. Materials and Methods: Biopsy from 20 esophageal growth processed conventionally, and histological section is stained by hematoxylin and eosin stains; paraffin-embedded tissue of esophageal lesions is processed and stained for immunohistochemistry in the detection of HPV by cocktail HPV16 and HPV18 antibodies by the standard procedure. Results: The present poster describes the results of immunohistochemistry for high-risk HPV on 20 cases of esophagus premalignant squamous cell lesions along with the SCC types and its grade. It has been observed that five cases have been demonstrated for positive results of immunohistochemistry for high-risk HPV. Conclusions: It may be postulated that HPV plays an important role in the pathogenesis of SCC esophagus.