Abstract
BackgroundThe mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.MethodsBetween 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes.ResultsCompared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38.60%, 74.60%, 87.50% and 89.05%, P < 0.001) and the positivity is also higher in SCC compared to CINI (P < 0.01). The most frequently detected genotypes were HPV16 in cervicitis, HPV16, 58 and 52 in CINI and CIN II/III, and HPV16, 58 and 18 in SCC groups. HPV16 positivity in cervicitis, CINI, CIN II/III, and SCC patients were 45.46%, 46.81%, 60.32% and 78.69%, respectively. Compared to cervicitis and CINI, the odds ratios (OR) for SCC in HPV16 positive patients were 2.96 (95% confidence interval [CI]: 1.09–8.00, P < 0.05) and 4.20 (95% confidence interval [CI]: 2.05–8.61, P < 0.001), respectively. In addition, the multiple infections in cervicitis, CINI, CINII/III and SCC group are 9.09%, 27.66%, 26.98% and 25.41% and HPV16 + 58 was the most common combinations.ConclusionThese findings highlight the key role of HPV16, 58, 52 and 18 in the development of CIN and SCC in Longnan women and a fully aware of regional differences in HPV genotype distribution are tasks for cervical cancer control and prevention.
Highlights
The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China
This study aims to investigate the prevalence and distribution of Human papillomaviruses (HPV) oncogenic genotypes in patients with cervicitis, CINI, CINII/III, or invasive squamous cell carcinoma (SCC) in Longnan
Genotypes detected in Cervicitis, CINI, CINII∕III and SCC We identified 329 eligible patients with a mean age of 43.5 years from the medical records
Summary
The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China. Genotypes HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59 are regarded as high risk types (hr-HPV) because they are identified in high-grade squamous intraepithelial lesions (HSIL) and invasive cervical cancer tissues [3,4,5]. The genotypes HPV6 and 11 are considered as low-risk types [4, 6]. Cervical cancer (CC) is a major fatal malignancy among women, causing about 265,700 deaths annually world-wide. 90% of cervical cancer deaths occur in developing countries, such as China [7]. The cervical cancer incidence in China is high, with 132,300 new cases each year, yielding a rate of 27 per 100,000 women [8].
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