Abstract
Many factors are involved in carcinogenesis of the ovary, such human genetic and physiological characteristics as lifestyle, existing diseases of the reproductive system, and, as suggested, the human papillomavirus (HPV). It is well known that the human papillomavirus virus of high carcinogenic risk (HCR) plays a crucial role in the onset and development of cervical cancer, as well as cases of HPV positive breast cancer and endometrial cancer. The data on the presence of HPV in ovarian cancer are ambiguous: the researchers claim that there is no complete effect of the virus on the development of this type of cancer, and the detection of HPV in 60–80% of tumors. In this regard, there is a need to systematize the currently available research results on this controversial issue and conduct a meta-analysis of the association of HPV infection with the risk of ovarian cancer. • HPV is found in ovarian cancer in 28.6% of cases, while in the samples of the control group the virus was detected in 8.8%. • Among patients from Europe, the prevalence of HPV in ovarian cancer was 31.2%. Among patients from Asia - 22.5%. • Europeans have a lower relative risk of developing ovarian cancer with HPV infection than Asians (RR 1.87 versus 3.61).
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