Abstract
BackgroundCervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human Papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific distribution in ICC have been conducted in Italy.AimTo describe the prevalence of HPV and the HPV type-specific distribution in ICC cases identified in Rome, Italy.Methods140 paraffin embedded tissue blocks of primary ICC diagnosed between 2001 and 2006 were identified at the Regina Elena Cancer Institute in Rome (Italy). HPV was detected through amplification of HPV DNA using SPF-10 HPV broad-spectrum primers followed by DEIA and then genotyping by LiPA25 (version 1).Results134 cases were considered suitable for HPV DNA detection after histological evaluation; and overall, 90.3% (121/134) HPV prevalence was detected. 111 cases had a single HPV type, 4 cases had an uncharacterized type (HPVX) and 6 cases had multiple HPV infections. The five most common single HPV types among positive cases were: HPV16 (71/121; 58.7%), HPV18 (12/121; 9.9%), HPV31, HPV45 and HPV58 (5/121; 4.1% each). 2 (1.5%) of the single infections and 2 (1.5%) of the multiple infections contained low risk types. Statistically significant differences in the relative contribution of HPV18 were found when comparing squamous cell carcinomas with adenocarcinomas.ConclusionsHPV16 and HPV18 accounted for almost 70% of all the HPV positive ICC cases. The study provides baseline information for further evaluation on the impact of recently introduced HPV vaccines in Italy.
Highlights
Cervical cancer represents an important global public health problem
HPV16 and HPV18 accounted for almost 70% of all the Human Papillomavirus (HPV) positive invasive cervical cancer (ICC) cases
Data from an updated metaanalysis conducted by the International Agency for Research on Cancer (IARC) [10,11] confirmed HPV16 as the most common type detected in ICC specimens worldwide, followed by HPV18, together accounting for 70% of the HPVs identified in ICC specimens
Summary
Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human Papillomavirus (HPV) infection is well-established as a necessary cause of invasive cervical cancer (ICC) development. Cervical cancer is a serious public health problem representing the 2nd most common cancer diagnosed among women worldwide. In this study we analyse and present data regarding Human Papillomavirus (HPV) in invasive cervical cancer (ICC) specimens from Italy, a country whose population consist of 25.94 million [2] women at risk of developing ICC (15 y.o. or older). A small fraction of women with cervical HPV infection develop ICC, suggesting that other co-factors besides HPV are necessary to cause cancer progression [6]. After HPV16/18, the 6 most common HPV types were found to be the same in all world regions (HPV45, 31, 33, 52, 58, and 35), with only slight differences in their relative frequency over continents but, accounting for an additional 20% of cervical cancers worldwide [10,11]
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