Abstract
BackgroundHuman Papilloma Virus (HPV) genotypes concordance among sexual couples has been evaluated in many investigations with considerable variations in the concordance. However, no such study has carried out between Iranian couples yet.MethodsUrogenital specimen from both males and females of couples were taken and transferred to Nilou laboratory for molecular analysis. HPV DNA extraction and typing were carried out using cobas 4800 platform. Demographic and virological data were analyzed afterwards.ResultsOne hundred fourteen couples were enrolled in the study. The mean age of participants were 36 ± 8 and 32 ± 7 for males and females, respectively. 64 (28%) of specimens were positive for at least one HPV genotype. The positive rates within genders were 30.7 and 25.4% for females and males, respectively with a considerable association (P value 0.021). Within the positive samples, 13(5.7%), 8 (7%) and 31(13.5%) were belonged to 16, 18 and other HR genotypes. 59 (51.8%) couples who were negative for HPV showed negative concordance. Of the total positive HPV patients (55 couples, 48.2%), 9 (16.3%) couples had positive concordance and the rest of 46 (83.7%) couples (either of spouse being negative and the other being positive for HPV) showed neither kinds of concordance.ConclusionRecognition of the dynamics of HPV infection not only in women, but in their sexual partners could impact the implementation of preventive measures like HPV vaccination for cervical cancer and other HPV-related diseases for both sexual partners.
Highlights
Human Papilloma Virus (HPV) genotypes concordance among sexual couples has been evaluated in many investigations with considerable variations in the concordance
The detected prevalence of HPV infection in male partners of women who were positive for HPV and/or cervical intraepithelial neoplasia or squamous carcinoma, ranged between 23 and 73% in several reports [4,5,6, 8]
Groups I consisted of 59 (51.8%) couples who Discussion HPV infection is very widespread among males and females across all geographical, racial and socioeconomic populations worldwide and is the only sexually transmitted disease that is difficult to be handled in both members of a sexual couple
Summary
Human Papilloma Virus (HPV) genotypes concordance among sexual couples has been evaluated in many investigations with considerable variations in the concordance. It is estimated that 40% of penile carcinomas are attributed to infection with high risk HPV [2,3,4] and approximately, 20% of all men Sexual behavior characteristics in both women and men are key determinants of HPV infection, worldwide. Previous reports confirmed that the sexual behavior of males can influence the risk of cervical cancer in their sexual partners [4,5,6,7]. The detected prevalence of HPV infection in male partners of women who were positive for HPV and/or cervical intraepithelial neoplasia or squamous carcinoma, ranged between 23 and 73% in several reports [4,5,6, 8]. HPV infection may be associated with lower mortality and morbidity in men, due to its association with
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