HUMAN PAPILLOMA VIRUS AND ITS REPLICATION CYCLE

Abstract

Human papilloma virus an Infected cell division and basal cell start the procedure of keratinocyte differentiation that the triggers a strongly orchestrated pattern to the productive infection of the viral gene infection (1). Ds DNA genome present in to the nuclei where in the epithelial cell dividing Cervical disease divided in to the high and low reason of the subset mucosa infective(2). Mostly high risk HPV infection during lifetime but cervical disease and cancer immune system recognizes and clear the virus (3). In men high risk human papilloma virus predomenentially a subset of or pharyngeal cancer and the women more than 99.7% in cervical cancer (4) .cancer progression is due to the persistent infection with the high risk human papilloma virus.one of the most common part cancer at the molecular level, cancer progression is due to the high expression of the viral oncoproteins E6 and E7, inhibit apoptosis and also accumulation of DNA damage and activate the cell cycle (5, 6)