Abstract
Diabetes and cardiovascular disease are the two most common deleterious side effects in the first line complications of chronic human obesity. Hyperleptinemia, hyperinsulinemia and hypercholesterolemia are the reported proximal outbreaks in progressive human obesity. Leptin, insulin and LDL remain interacted through their cognate receptors. A phase matched comparison has been conducted in present study between expressions of cognate receptors and plasma profile of their respective ligands in three human male groups viz. normal (18.5< BMI < 25), obese (25< BMI <40) and morbid obese (BMI > 40). Our study shows a declined leptin receptor concentration on peripheral blood mononuclear cells (PBMC) with a meagre change in its soluble counterpart (sOR/ OB-Re) in blood circulation, averring the outbreak of hyperleptinemia with obesity. Simultaneously, a cumulative decline of concentrations of LDL receptor (LDLR) and insulin receptor (IR) in PBMC are the reasons behind hypercholesterolemia and hyperinsulinemia cum insulin resistance in human obesity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
