Abstract
Human Neutrophils in Patients with Positive Serology for Chagas Disease
Highlights
It was reported that neutrophils participate in a key role in the effector and regulatory mechanisms of innate and adaptive responses [1,2,3]
Materials and Methods: Quantification of ring cells in smears of heparinized human blood samples with and without positive serology for Chagas; testing with cytochemical reaction for myeloperoxidase (MPO) technique; autologous cell cultures; LPS assay to generating NETs, DNA visualized with DAPI in Immunofluorescence Microscopy; ultrastructural study with Transmission Electron Microscopy (TEM)
No significant differences in blood smears in the number of neutrophils with ring nuclei between sexes were found in both groups (H and Chagas positive serology (CH))
Summary
It was reported that neutrophils participate in a key role in the effector and regulatory mechanisms of innate and adaptive responses [1,2,3]. Neutrophils are called polymorphonuclear (PMN) because their nucleus may have three to five lobes connected by thin chromatin bridges. It has been proposed that the protein composition of the nuclear envelope of neutrophils allows them “deformability” of its nucleus and would facilitate the migration of activated cells from the vessels to sites of infection and lobulation and forms in ring [4,5]. The ring shaped nuclei in neutrophils were composed of three or four areas lobed completely connected to each other, some of them by a thin strip of DNA. In some pathologies, such as infectious mononucleosis, myelodysplastic syndromes and others, ring shaped nuclei were observed in human neutrophils [8,9,10,11,12,13,14,15]
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