Abstract
The primary granule protein (PGP), human neutrophil elastase (HNE), is often associated with inflammatory-type reactions but also has a role in granulopoiesis.1 PGP proteases, including HNE, normally provide negative feedback of granulopoiesis by controlling the availability of granulocyte colony-stimulating factor (G-CSF) proportionate to the relative abundance of mature granulocytes that are greatly elevated in number as a clinical feature of chronic myeloid leukaemia (CML).
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