Human Nedd4L rs4149601 G Allele Generates Evolutionary New Isoform I With C2 Domain

Abstract

To the Editor: We carefully read the recent article in Hypertension by Luo et al.1 They found that the human Nedd4L functional variant (rs4149601 [G/A]) shows significant functional relevance with various phenotypes of human hypertension. However, they repeatedly emphasized in the article that, “the cryptic splice variant rs4149601 (G/A) …