Human Metapneumovirus Induces Mucin 19 Which Contributes to Viral Pathogenesis.

Kaitlin Mcbride,Nagarjuna R Cheemarla,Antonieta Guerrero-Plata,Ma Del Rocio Banos-Lara

doi:10.3390/pathogens9090726

Kaitlin Mcbride, Nagarjuna R Cheemarla + Show 2 more

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https://doi.org/10.3390/pathogens9090726

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Journal: Pathogens (Basel, Switzerland)	Publication Date: Sep 3, 2020
Citations: 3	License type: CC BY 4.0

Affiliation: Louisiana State University

Abstract

Human Metapneumovirus (HMPV) remains one of the most common viral infections causing acute respiratory tract infections, especially in young children, elderly, and immunocompromised populations. Clinical symptoms can range from mild respiratory symptoms to severe bronchiolitis and pneumonia. The production of mucus is a common feature during HMPV infection, but its contribution to HMPV-induced pathogenesis and immune response is largely unknown. Mucins are a major component of mucus and they could have an impact on how the host responds to infections. Using an in vitro system and a mouse model of infection, we identified that Mucin 19 is predominantly expressed in the respiratory tract upon HMPV infection. Moreover, the lack of Muc19 led to an improved disease, lower lung viral titers and a decrease in the number of CD4+ T cells. These data indicate that mucin 19 contributes to the activation of the immune response to HMPV and to HMPV-induced pathogenesis.

Highlights

Human metapneumovirus (HMPV) is a negative sense, single-stranded RNA virus belonging to the newly formed Pneumoviridae family [1]
We initially initially explored explored the the expression expression of of mucins mucins induced induced by Human Metapneumovirus (HMPV) in vitro, using normal human bronchial epithelial cells (NHBE)
We have previously reported that HMPV induced Mucin 19 in human (MUC19) in A549 cell line [18], no significant induction was observed in those cells

Summary

Introduction

Human metapneumovirus (HMPV) is a negative sense, single-stranded RNA virus belonging to the newly formed Pneumoviridae family [1]. HMPV was discovered in 2001, it is believed to have been present for at least 50 years [2]. HMPV infects people of all ages, but the populations most at risk for severe illness are the elderly, the immunocompromised and children [3]. By 5 years of age, virtually all children have been infected with HMPV. Symptoms of HMPV often include those common to other respiratory illnesses: rhinorrhea, cough, or fever. Some individuals with severe disease exhibit bronchiolitis or even pneumonia, and may be hospitalized [4]. There is not an effective vaccine against HMPV [5]

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