Human lung on a chip: innovative approach for understanding disease processes and effective drug testing

Jutaro Fukumoto,Narasaiah Kolliputi

doi:10.3389/fphar.2012.00205

Abstract

Human lung on a chip: innovative approach for understanding disease processes and effective drug testing

Highlights

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice by Dongeun Huh et al (2012)
One of the most outstanding hallmarks of lung pathology in Acute lung injury (ALI) is pulmonary edema. It is preceded by high vascular pressure and/or increased alveolarcapillary permeability, which cause the influx of vascular leakage into the alveolar space that leads to pulmonary edema
Hospitalization and mortality rates associated with pulmonary edema are significantly high

Summary

Introduction

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice by Dongeun Huh et al (2012). The development of new drugs toward pulmonary edema and ALI is at present hindered by the poor predictive power of existing preclinical animal models.

Results

Conclusion