Abstract
The Human Liver Proteome Project is the first initiative of the human proteome project for human organs/tissues and aims at writing a modern Prometheus myth. Its global scientific objectives are to reveal the "solar system" of the human liver proteome, expression profiles, modification profiles, a protein linkage (protein-protein interaction) map, and a proteome localization map, and to define an ORFeome, physiome, and pathome. Since it was first proposed in April 2002, the Human Liver Proteome Project has attracted more than 100 laboratories from all over the world. In the ensuing 3 years, we set up a management infrastructure, identified reference laboratories, confirmed standard operating procedures, initiated international research collaborations, and finally achieved the first set of expression profile data.
Highlights
Once one talks about the liver, one might call to mind the ancient Greek myth about Prometheus
The liver is the source of a major portion of the fatty acids sent to other organs to be used as the primary source of energy in the fasted state and is the major site for synthesis of fatty acids from excess sugar in the fed state
The liver plays a major role in determining the pharmacokinetics of a drug because it is the major organ of drug elimination through its metabolic capacity and biliary excretion; it influences the distribution of drugs via the synthesis of their binding proteins
Summary
The Human Liver Proteome Project is the first initiative of the human proteome project for human organs/tissues and aims at writing a modern Prometheus myth. Its global scientific objectives are to reveal the “solar system” of the human liver proteome, expression profiles, modification profiles, a protein linkage (protein-protein interaction) map, and a proteome localization map, and to define an ORFeome, physiome, and pathome. Since it was first proposed in April 2002, the Human Liver Proteome Project has attracted more than 100 laboratories from all over the world. As the first initiative on human tissues/organs, HLPP aims to 1) generate an integrative approach leading to a comprehensive protein atlas of the liver, 2) expand the liver proteome to its physiome and pathome to dramatically accelerate the development of diagnostics and therapeutics toward liver diseases, and 3) develop standard operating procedures (SOPs) for other HUPO initiatives
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