Abstract
The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both clinical and genetic factors that determine its success. Genetic factors including human leukocyte antigen (HLA) and non-HLA genetic variants are believed to influence the risk of potentially fatal complications after the transplant. Moreover, ethnicity has been proposed as a factor modifying the risk of graft-versus-host disease. The populations of Latin America are a complex array of different admixture processes with varying degrees of ancestral population proportions that came in different migration waves. This complexity makes the study of genetic risks in this region complicated unless the extent of this variation is thoroughly characterized. In this study we compared the HLA-A and HLA-B allele group profiles for 31 Latin American populations and 61 ancestral populations from Iberia, Italy, Sub-Saharan Africa, and America. Results from population genetics comparisons show a wide variation in the HLA profiles from the Latin American populations that correlate with different admixture proportions. Populations in Latin America seem to be organized in at least three groups with (1) strong Amerindian admixture, (2) strong Caucasian component, and (3) a Caucasian-African gradient. These results imply that genetic risk assessment for HSCT in Latin America has to be adapted for different population subgroups rather than as a pan-Hispanic/Latino analysis.
Highlights
Hematopoietic stem cell transplantation (HSCT) is a curative therapy used for the treatment of malignant and nonmalignant hematologic diseases, congenital immune deficiencies, solid tumors, and metabolic diseases [1]
The human leukocyte antigen (HLA)-A and HLA-B profiles of the 92 populations were analysed by clustering analysis and Principal Coordinates Analysis (PCO), both based on Euclidean distances
A dendrogram based on squared Euclidean distances was generated by the comparison of 47 HLA-A and HLA-B allele group frequencies present in the 61 ancestral populations and the 31 Latin American Populations (LAP)
Summary
Hematopoietic stem cell transplantation (HSCT) is a curative therapy used for the treatment of malignant and nonmalignant hematologic diseases, congenital immune deficiencies, solid tumors, and metabolic diseases [1]. Bone Marrow Research last continent humanity had expanded to [12], through the 16th and 17th centuries European colonization and bringing of sub-Saharan African (SSA) slaves [13], to the latest waves of immigrants from all over the world in the last two centuries [14]. This complex population history makes present Latin American Populations (LAP) possibly the most ethnically diverse on the planet. We used population genetics tools to compare the HLA profiles of 31 LAP and 61 ancestral populations in order to characterise their diversity and classify them according to their genetic makeup
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
