Abstract
Background: Gastro oesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to Gastro oesophageal reflux disease as supported by familial aggregation of this disease. Aim of the study was to investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with (GERD).Methods: Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016. Sixty Iraqi Arab Muslim patients with a history of heartburn and dyspepsia were compared with 100 Iraqi Arab Muslims controls. All study patients and control groups underwent upper gastrointestinal endoscopic examinations and their serums were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori. HLA-DRB1 genotyping were done to both groups.Results: A total of 60 patients with erosive gastritis; GERD (Grade II and III) were evaluated, together with 100 controls. There is a significant increase of H. pylori infection (p=0.0001) in GERD patients than control group. HLA-DRB1* 15: 01was significantly increased in GERD patients in comparison with control group and an increased frequency of HLADRB1*11: 01 in control group compared with patients group.Conclusions: There is an association between HLA-DRB1 *15: 01 in GERD patients with H pylori positive patients.J MEDICINE Jan 2018; 19 (1) : 3-9
Highlights
Gastro-oesophageal reflux disease (GERD) is the end results of involuntary gastric contents reflux into the oesophagus, causing heartburn and acid regurgitation symptoms or injury to oesophageal tissue.[1,2] oesophagitis is considered as a complication of GERD.[3]
We examine if the human leucocyte antigen Human Leukocyte Antigen (HLA)-DRB1 alleles, important for immune responsiveness, may be a susceptibility locus for GERD disease in Iraqi Arab Muslims patients
There is a significant increase of H. pylori infection (p=0.0001) in GERD patients than control group
Summary
Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016. Sixty Iraqi Arab Muslims patients with a history of heartburn and dyspepsia at least three times a week for a period of more than three months and had been referred for upper gastrointestinal endoscopy at GIT center at Al-Kindy Teaching Hospital, Baghdad and a diagnosis of GERD were prospectively recruited. Exclusion criteria included those patients with Barrett’s oesophagus and esophageal varices, Patients with secondary causes of gastro-oesophageal reflux disease, patients who had consumed antacids, H2 blockers, proton pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), alcohol, history of Helicobacter pylori eradication, subjects with a history of gastrointestinal surgery, peptic ulcer, and gastric cancer or with systemic disease requiring chronic medication were excluded. P-value less than 0.05 were considered statistically significant
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