Abstract
Of the more than 120 phytocannabinoids present in Cannabis plants, cannabidiol (CBD) in particular has garnered a great deal of attention due to emerging evidence of its therapeutic potential in various disorders characterised by hyperexcitability. Studies indicate that CBD reduces hyperexcitability through inhibition of voltage-gated sodium channels. However, whether activation of potassium channels also contributes to the therapeutic benefits of CBD remains largely unstudied. Here, we assess the effects of CBD on the KV7 channel family comprised of five subtypes, KV7.1-7.5, which are distributed across various tissues and make important physiological contributions.
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