Abstract
Pancreatic juice is supersaturated with calcium carbonate. Calcium carbonate (CaCO3) crystal growth is controlled by lithostathine, a secretory protein synthesized by pancreatic acinar cells, first described as a constituent of pancreatic stones1. It was recently reported that in the thin descending limb of the Henle’s loops of rat kidneys, urine is supersaturated with CaCO3 and calcium phosphate2. This observation suggested the presence in kidney of a similar inhibitor.
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