Abstract
Opinion statementStem cell therapy is a promising therapeutic option for severe cardiac diseases that are resistant to conventional therapies. To overcome the unsatisfactory results of most clinical researches on stem cell injections to an injured heart, we are developing bioengineered cardiac tissue grafts using pluripotent stem cell-derived cardiomyocytes and vascular cells. We have validated the functional benefits of mouse embryonic stem cell-derived and human induced pluripotent stem cell-derived cardiac tissue sheets (CTSs) in a rat myocardial infarction model. We further showed enhanced functional recovery and engraftment efficiency leading to de novo myocardium upon transplanting thick multi-layered CTSs that had gelatin hydrogel microspheres between the layers. We anticipate that the combination of pluripotent stem cell biology and tissue engineering will contribute to future stem cell therapies for severe heart diseases.
Highlights
Cardiovascular disease remains a major cause of death with increasing medical costs worldwide despite great advances in therapeutic modalities and risk-reduction strategies [1]
We introduce our strategy, which combines cardiovascular cell differentiation from human induced pluripotent stem cells and bioengineered 3D cardiac tissues based on cell sheets, to effectively engraft transplants for stem cellbased cardiac regenerative therapy
We have reported that cardiovascular cell types can be systematically differentiated from mouse Induced pluripotent stem cells (iPSCs) in almost the same manner as from mouse Embryonic stem cells (ESCs) [44], suggesting iPSCs and ESCs hold similar cardiac regenerative capacities
Summary
Cardiovascular disease remains a major cause of death with increasing medical costs worldwide despite great advances in therapeutic modalities and risk-reduction strategies [1].
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