Human intestinal parasites.

Abstract

Parasitic infections, caused by intestinal helminths and protozoan parasites, are among the most prevalent infections in humans in developing countries. In developed countries, protozoan parasites more commonly cause gastrointestinal infections compared to helminths. Intestinal parasites cause a significant morbidity and mortality in endemic countries. Helminths are worms with many cells. Nematodes (roundworms), cestodes (tapeworms), and trematodes (flatworms) are among the most common helminths that inhabit the human gut. Usually, helminths cannot multiply in the human body. Protozoan parasites that have only one cell can multiply inside the human body. There are four species of intestinal helminthic parasites, also known as geohelminths and soil-transmitted helminths: Ascaris lumbricoides (roundworm), Trichiuris trichiuria (whipworm), Ancylostoma duodenale, and Necator americanicus (hookworms). These infections are most prevalent in tropical and subtropical regions of the developing world where adequate water and sanitation facilities are lacking (1,2). Recent estimates suggest that A. lumbricoides can infect over a billion, T. trichiura 795 million, and hookworms 740 million people (3). Other species of intestinal helminths are not widely prevalent. Intestinal helminths rarely cause death. Instead, the burden of disease is related to less mortality than to the chronic and insidious effects on health and nutritional status of the host (4,5). In addition to their health effects, intestinal helminth infections also impair physical and mental growth of children, thwart educational achievement, and hinder economic development (6,7). The most common intestinal protozoan parasites are: Giardia intestinalis, Entamoeba histolytica, Cyclospora cayetanenensis, and Cryptosporidium spp. The diseases caused by these intestinal protozoan parasites are known as giardiasis, amoebiasis, cyclosporiasis, and cryptosporidiosis respectively, and they are associated with diarrhoea (8). G. intestinalis is the most prevalent parasitic cause of diarrhoea in the developed world, and this infection is also very common in developing countries. Amoebiasis is the third leading cause of death from parasitic diseases worldwide, with its greatest impact on the people of developing countries. The World Health Organization (WHO) estimates that approximately 50 million people worldwide suffer from invasive amoebic infection each year, resulting in 40-100 thousand deaths annually (9,10). Cryptosporidiosis is becoming most prevalent in both developed and developing countries among patients with AIDS and among children aged less than five years. Several outbreaks of diarrhoeal disease caused by C. cayetanensis have been reported during the last decade (11). Spread of these protozoan parasites in developing countries mostly occurs through faecal contamination as a result of poor sewage and poor quality of water. Food and water-borne outbreaks of these protozoan parasites have occurred, and the infectious cyst form of the parasites is relatively resistant to chlorine (12). Other species of protozoan parasites can also be found in the human gut, but they are not pathogenic, except Microsporidia sp. In an article published in this issue of the Journal, Jacobsen et al. looked at the prevalence of intestinal parasites in young Quichua children in the highland or rural Ecuador (13). They have found a high prevalence of intestinal parasites, especially the intestinal protozoan parasites. They have used the traditional microscopic technique to diagnose intestinal parasitic infections. In total, 203 stool samples were examined from children aged 12-60 months and found that 85.7% of them had at least on parasite. The overall prevalence of intestinal protozoan parasites were: E. histolytica/E. dispar 57.1%, Escherichia coli 34.0%, G. intestinalis 21.1%, C. parvum 8.9%, and C. mesnili 1.7%, while the prevalence of intestinal helminthic parasites in this study were: A. …