Abstract
Cryptosporidium parvum (C. parvum) is a coccidian parasite of the phylum Apicomplexa that infects the gastrointestinal, biliary and respiratory epithelium of humans and animals. Early reports described a disease in humans characterized by protracted, watery diarrhea occurring in immunosuppressed patients, many with acquired immunodeficiency syndrome (AIDS). Recent epidemiologic studies indicate that cryptosporidiosis may also present as an acute, self-limited diarrheal disease in immunocompetent individuals and may account for 1%-10% of diarrheal disease worldwide. Despite the magnitude and severity of cryptosporidial infection, the pathogenesis is poorly understood, and there is currently no effective therapy. In this review, we provide a concise summary of what is known about cryptosporidial infection of the intestinal and biliary tract.
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