Abstract
Five human cases of infection with the simian malaria parasite Plasmodium knowlesi from Palawan, the Philippines, were confirmed by nested PCR. This study suggests that this zoonotic infection is found across a relatively wide area in Palawan and documents autochthonous cases in the country.
Highlights
Five human cases of infection with the simian malaria parasite Plasmodium knowlesi from Palawan, the Philippines, were confirmed by nested PCR
Blood films of 2 patients (A and B), whose condition was diagnosed by microscopy as P. malariae at a local laboratory in Palawan, were sent to the malaria national reference laboratory of the Research Institute for Tropical Medicine (RITM) in Manila
DNA was extracted from the 2 slides as detailed previously [8] and examined by nested PCR assays for P. falciparum, P. vivax, P. malariae, P. knowlesi, and P. ovale as described by Singh and co-workers [2]
Summary
Five human cases of infection with the simian malaria parasite Plasmodium knowlesi from Palawan, the Philippines, were confirmed by nested PCR. Human malaria is commonly caused by Plasmodium falciparum, P. vivax, P. malariae, and P. ovale. The diagnosis of P. knowlesi in humans may be missed by microscopy since the early blood stages of P. knowlesi morphologically resemble P. falciparum; the mature blood stages and gametocytes are similar to those of P. malariae [2].
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