Abstract
In investigating influenza in an immunodeficient child in China, in December 2010, we found that the influenza virus showed high sequence identity to that of swine. Serologic evidence indicated that viral persistence in pigs was the source of infection. Continued surveillance of pigs and systemic analysis of swine influenza isolates are needed.
Highlights
In investigating influenza in an immunodeficient child in China, in December 2010, we found that the influenza virus showed high sequence identity to that of swine
Humans have been infected with avian-like swine influenza A (H1N1) viruses (SIVs) several times since the first case was diagnosed in Switzerland in 1986 [1]
The Sw/JS/40/11 and JS/1/11 isolates have the amino acids D at site 190 and E at site 225 within the HA protein, which implies that these viruses might preferentially bind to α-2,6–linked sialosides
Summary
In investigating influenza in an immunodeficient child in China, in December 2010, we found that the influenza virus showed high sequence identity to that of swine. Humans have been infected with avian-like swine influenza A (H1N1) viruses (SIVs) several times since the first case was diagnosed in Switzerland in 1986 [1]. The A (H1N1) viruses isolated in this study fell into the European avian-like swine A (H1N1) lineage (Figure 1).
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