Abstract
BackgroundTuberculosis (TB) is among the world’s top public health challenges and the leading killer of people with HIV, yet is a treatable disease. This study aimed to assess, in a real-world setting, the implementation of antiretroviral therapy (ART) and Cotrimoxazole preventive therapy (CPT) policy, specific interventions proven to benefit patients in HIV-associated TB care.MethodsThis retrospective cohort study was conducted in Botswana in the Serowe/Palapye district, a largely urban district with a high burden of HIV-associated TB with a high case fatality, at Segkoma and Palapye hospitals and their feeder clinics. Between 1 January 2013 and 31 December 2013, confirmed HIV-positive patients aged ≥15 years with a confirmed TB diagnosis and medical record available were included in the analysis. The Kaplan-Meier method was used to compare time to death for the group of patients on ART and the group of patients not on ART during TB treatment. Cox proportional hazard regression was undertaken to identify predictors of mortality.ResultsOf the 300 patients included in the study, 217 (72%) were ART experienced at TB diagnosis. Of these, 86 (40%) had TB within 3 months following ART initiation. Of the 83 (28%) patients who were ART-naïve at TB diagnosis, 40 (48%) were commenced on ART during TB treatment, with 24 (60%) patients commencing within 4 weeks following TB treatment initiation. The overall ART uptake was 84%, while cotrimoxazole preventive therapy uptake was 100%. There were 45 deaths (15%), ART-experienced patients during TB treatment accounted for 30 deaths (30/257; 14%), while those who were not ART-experienced during TB treatment accounted for 15 deaths (15/43; 35%). There was a significant difference in survival time between patients with no ART use during TB treatment and those with ART use during TB treatment (log rank p < 0.001). Patients with no ART use during TB treatment were more likely to die within the first 2 months.ConclusionThe implementation of CPT policy is a substantial success. Strengthening the implementation of ART policy could improve survival among HIV-associated TB patients.
Highlights
Tuberculosis (TB) is among the world’s top public health challenges and the leading killer of people with Human immunodeficiency virus (HIV), yet is a treatable disease
Between 1 January 2013 and 31 December 2013, 551 TB patients were initiated on TB treatment in the Serowe/ Palapye district, 388 (70%) of them were co-infected with HIV
antiretroviral therapy (ART)-experienced patients during TB treatment accounted for 30 deaths (30/257; 14%), with 18 deaths (18/131; 14%) amongst those who had been on ART for ≥3 months at the time of their TB diagnosis and 12 deaths (12/126; 10%) amongst those with recent ART initiation
Summary
This study aimed to assess, in a real-world setting, the implementation of antiretroviral therapy (ART) and Cotrimoxazole preventive therapy (CPT) policy, specific interventions proven to benefit patients in HIV-associated TB care. Tuberculosis (TB) is among the world’s top public health challenges and the leading killer of people with HIV, yet is a treatable disease [1, 2]. In 2017, there were an estimated 10 million cases of TB, and of these 10% were co-infected with HIV [2]. The number of deaths from TB in HIV-negative patients was 1.3. The HIV infection has markedly increased morbidity and mortality of Tuberculosis [4, 5]. Interventions to improve HIV-associated TB care have been found, and these form important components of the international standard of care for TB [6]
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