Abstract
Background Breast milk is a component of the mucosal immune system, and contains specific antibodies and lymphocytes that may modulate the infectivity of milk, and therefore the risk of HIV-1 transmission via breastfeeding. While secretory antibodies (Ab) have been extensively explored in human breast milk, the existence, features, and function of B lymphocytes remain to be described in this compartment.
Highlights
Breast milk is a component of the mucosal immune system, and contains specific antibodies and lymphocytes that may modulate the infectivity of milk, and the risk of HIV-1 transmission via breastfeeding
In contrast to their blood counterpart, naive B cells remained largely underrepresented in breast milk
Breast milk B cells mostly consisted of IgD- memory B cells
Summary
Edouard Tuaillon*1, Diane Valea, Yassine Al Tabaa, Pierre Becquart, Nicolas Meda, Karine Bollore, Jean-Pierre Vendrell and Philippe Van de. Address: 1Université Montpellier 1 and CHU Montpellier, Montpellier, France and 2Centre Muraz, Bobo-Dioulasso, Burkina Faso * Corresponding author from Fifth Dominique Dormont International Conference. Mother-to-child transmitted viral diseases: from transmission to children care Paris, France. Published: 22 July 2009 Retrovirology 2009, 6(Suppl 1):O8 doi:10.1186/1742-4690-6-S1-O8. Fifth Dominique Dormont International Conference. Host-Pathogen Interactions in Chronic Infections Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-6-S1-info.pdf
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