Human Immunodeficiency Virus Infection and Status Epilepticus in United States (2002-2009) (P07.114)

Abstract

Objective: To determine the association between human immunodeficiency virus (HIV) infection and status epilepticus, and compare the outcomes of patients with status epilepticus with or without underlying HIV infection. Background The direct neurotropic effect of HIV virus has been implicated in such cases. An undetermined proportion of such patients develop status epilepticus. However, it remains unknown whether HIV infection is a risk factor for status epilepticus because of the small sample sizes of most studies and the lack of well-designed case-control studies. Design/Methods: Patients with primary diagnosis of status epilepticus (cases) and status asthmaticus (controls) were identified from the 2002-2009 Nationwide Inpatient Sample (NIS) which is representative of all admissions in the United States. We performed logistic regression analysis adjusting for age, gender, co-morbid conditions including hypertension, diabetes mellitus (DM), renal failure, alcohol use, and opportunistic infections. We compared the in hospital outcomes among patients admitted with status epilepticus in strata defined by underlying HIV infection. Results: The rate of concurrent status epilepticus and HIV has increased over the last 7 years in hospitalized patients with status epilepticus in United States (0.14%-0.27% p Conclusions: Our study suggests that there is a direct association between HIV infection and status epilepticus. The proportion of patients admitted with concurrent status epilepticus and HIV infections is increasing and such patients have higher rates of poor discharge outcomes. Disclosure: Dr. Chaudhry has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Majidi has nothing to disclose. Dr. Bundlie has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Hassan has nothing to disclose. Dr. Suri has nothing to disclose. Dr. Qureshi has nothing to disclose.