Human immunodeficiency virus (HIV) infection and ovarian granulosa cell tumour in association with endocrine manifestations

Abstract

Granulosa cell tumours are uncommon ovarian tumours constituting 3-7% of all ovarian tumours and 70% of all sex-cord-stromal tumours. These tumours have unquestionable malignant potential and although the majority (68%) of patients present with early stage disease with good prognosis there is a tendency for late relapses. Although oestrogen hormone production by these tumours is well described masculinising effects from androgen production have also been reported. From a literature search there are no reports of ovarian granulosa cell tumours in association with HIV infection. We describe the presentation management and outcome of a patient with ovarian granulosa cell tumour with a background of HIV infection. (excerpt)