Abstract
Immunodeficiency-associated Burkitt lymphoma is a variant of Burkitt lymphoma and occurs frequently in human immunodeficiency virus (HIV)-infected adult patients with high a CD4 T-cell count. A 37-year-old HIV-positive male patient with leukoderma presented with an asymptomatic swelling of 6 months’ duration in left submandibular region, 6 cm in diameter, with a slightly wavy surface and solid consistency. The clinical diagnostic hypothesis was a salivary gland tumor. The ultrasonography revealed an expansive process with a lobed outline in the submandibular gland without lymphadenomegaly or local alteration. Excisional biopsy was performed and histopathologic analysis revealed malignant neoplasia with proliferation of lymphocyticlike cells exhibiting pleomorphism and vacuolated nuclei, evident nucleoli, abundant mitoses, and the presence of hyperchromatic cells in a “starry-sky” pattern. The histopathologic diagnosis compatible with Burkitt lymphoma was established. Immunohistochemical panel showed positive marking for CD20, CD10, and Ki-67 (95%), and a negative marking for Bcl-2, favoring the diagnosis of Burkitt lymphoma. The patient was immediately referred to chemotherapy treatment and after 1 year of follow-up, there is no evidence of recurrence.
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