Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex

Abstract

Human intracranial encephalography (iEEG) recordings have recently been used to define subjective mood states in amygdala-hippocampus-prefrontal cortical brain rhythms. The existence of defined patterns of brain activity thus represents a mechanistically based target for electrical stimulation to alter persistent negative emotional states which define psychiatric diagnoses. However, gaps exist in our knowledge of how anxiety- or threat-related behaviors elicit these brain rhythms across the threat imminence continuum.