Abstract
A human thymus cell hybridoma secretes an immunosuppressive lymphokine, referred to as hybridoma suppressor factor (HSF). This factor suppresses polyclonal immunoglobulin (Ig) production as well as Interleukin-2 (IL-2) production in pokeweed mitogen (PWM)-stimulated peripheral blood mononuclear cells (PBMC). Similar suppression of Ig and IL-2 production was observed in reconstituted cultures of CD4+ cells and non-T cells. Here we analysed, further, the mechanism of HSF-mediated suppression of Ig and IL-2 production. We demonstrated that HSF inhibited PWM-induced IL-2 production by CD4+ cells but not by CD8+ cells and its suppressive activity on Ig production was totally abrogated by preabsorption with CD4+ cells, but not by CD8+ cells. These results indicate a subset specific action of HSF.
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